Physicochemical Characteristics and Sub Chronic Oral Toxicity of <i>Pistacia lentiscus</i> L. Vegetable Oil in Rabbits

Toxicity Evaluation of Essential oil of Trachyspermum ammi in Acute and Sub-chronic Toxicity Experiments

Background: Trachyspermum ammi is one of the prominent plant in traditional medicine of the east with several medicinal effects such as improvement of stomach disease, digestive disorder, diarrhea, hemorrhoid, bladder stones, respiratory disease and etc. Medicinal plants is one of the important reason of toxicity particularly in children and the elderly therefore, evaluation of the toxic effect...

Sub-Chronic Toxicity Study of Alpha-Cypermethrin in Rats

Alpha-cypermethrin (?-CP) a synthetic pyrethroid (type-II) insecticide, dissolved in dimethyl sulfoxide (DMSO-1ml) given consecutive daily orally for 60 days at 1/10LD50 (14.5mg/kg). The animals were sacrificed on day 61st. Biochemicals, cytochromeP450, b5 contents in liver along with antioxidant status, tissue residual concentration, and brain GABA level were studied. It increased the serum am...

Sub-chronic Oral Toxicity Test Repeated Dose 90 - Day Oral Toxicity Study in Non-rodents

Acute and sub-acute oral toxicity of ethanol extract of Cassia fistula fruit in male rats

Objective: The plantCassia fistula L. (Caesalpiniaceae) is traditionally used to treat heart diseases, abdominal pain and fever. The present study was aimed to investigate the toxic effects acute and sub-acute administration of ethanol extract of C. fistula fruit (CFE) in male Wistar rats. Materials and Methods: In acute toxicity, the effects of a single oral dose (1000, 3000 and 5000 mg/kg) of...

Effects of Nigella sativa oil and ascorbic acid against oxytetracycline-induced hepato-renal toxicity in rabbits

Objective(s):  Oxytetracycline (OTC) is a broad spectrum antibiotic widely used for treatment of a wide range of infections. However, its improper human and animal use leads to toxic effects, including hepatonephrotoxicity. Our objective was to evaluate protective effects of Nigella sativa oil (NSO) and/or ascorbic acid (AA), against OTC-induced hepatonephrotoxicity in rabbits. Materials and Me...